Charles Fleischer

Roger Rabbit (voice)

April Winchell

Young Baby Herman / Mrs. Herman (voice)

Lou Hirsch

Adult Baby Herman (voice)

Corey Burton

Orderly (voice)

Kathleen Turner

Jessica Rabbit (voice)

Sol Pavlovsky

Raoul J. Raoul

William Bronder

Sign Carrier

Charles Noland

Sign Carrier

Richard Williams

Droopy Dog (voice)

June Foray

Nurse (voice) (uncredited)